Independent Research
Members of the Fang lab in Bold
* indicates equal contribution; # indicates corresponding authors
2026
21. Shentu J, Jiang Z, Tan Q, Fang L#, submitted. [Patent]
2025
20. Choi J, Jung TU, Cabanting F, Song J, Park C, Hwang S, Kang JY, Fang L, Jun YW#, Harnessing Deaminated DNA to Modulate mRNA Translation for Controlled and Sequential Protein Expression, Angew. Chem. Int. Ed., 2025, 64(52), e16389. [PDF]
Before Westlake
19. Stoddard EG, Fang L, Zhong Y, Potter ZE, Brush DS, Simon JJ, Golkowski M, Maly DJ#, Interactions with Mek Tune the Sensitivity of Raf Kinases to Conformation-Selective Inhibition, In revision. [BioRxiv]
18. Fang L*, Zhong W*, Xiao L, Bravo S, Shioi R, Lee A, Bravo CH, Kool ET#, Localized 2´-OH Acylation at Poly(A) Extends mRNA Translation, J. Am. Chem. Soc., 2025, 147(37), 34027-34033. [Patent available]
17. Pandit B, Fang L, Kool ET, Royzen M#, Reversible RNA Acylation Using Bio-Orthogonal Chemistry Enables Temporal Control of CRISPR-Cas9 Nuclease Activity, ACS Chem. Biol., 2024, 19(8), 1719-1724.
16. Xiao L, Fang L, Zhong W, Kool ET#, RNA infrastructure profiling illuminates transcriptome structure in crowded spaces, Cell Chem. Biol., 2024, 31(12), 2156-2167.e2155.
15. Fang L, Velema WA, Lee Y, Xiao L, Mohsen MG, Kietrys AM, Kool ET#, Pervasive Transcriptome Interactions of Protein-Targeted Drugs, Nat. Chem., 2023, 15, 1374-1383.
14. Fang L, Xiao L, Jun YW, Onishi Y, Kool ET#, Reversible 2´-OH Acylation Enhances RNA stability, Nat. Chem., 2023, 15, 1296-1305. [Patent available]
13. Fang L, Kool ET#, Reactivity-Based RNA Profiling for Analyzing Transcriptome Interactions of Small Molecules in Human Cells, STAR Protocols, 2023, 4, 102670.
12. Fang L, Chakraborty S, Dieter EM, Potter ZE, Lombard CK, Maly DJ#, Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes, J. Am. Chem. Soc., 2019, 141, 30, 11912-11922.
11. Fang L, Vilas-Boas J, Chakraborty S, Potter ZE, Register AC, Seeliger MA, Maly DJ#, How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture, ACS Chem. Biol., 2020, 15, 7, 2005-2016.
10. Xiao L, Fang L, Kool ET#, 2´-OH as a Universal Handle for Studying Intracellular RNAs, Cell Chem. Biol., 2023, 31, 110-124. Review article.
9. Xiao L, Fang L, Chatterjee S, Kool ET#, Diverse Reagent Scaffolds Provide Differential Selectivity of 2´-OH Acylation in RNA, J. Am. Chem. Soc., 2023, 145, 143-151.
8. #Chakraborty S, #Ahler E, Simon JJ, Fang L, Potter ZE, Sitko KA, Stephany JJ, Guttman M, Fowler DM, Maly DJ#, Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to the dynamics of the catalytic domain, Cell Chem. Biol., 2023, 23, 2451-9456.
7. Xiao L, Fang L, Kool ET#, Acylation Probing of ‘Generic’ RNA Libraries Reveals Critical Influence of Loop Constraints on Reactivity, Cell Chem. Biol., 2022, 29, 1–12.
6. Fang L, Maly DJ#, Finding the Right Key to the Lock: A Chemical and Genetic Toolkit for Interrogating DCLK1, Cell Chem. Biol., 2020, 27, 10, 1221-1223. Preview article.
5. Potter ZE, Lau H, Chakraborty S, Fang L, Guttman M, Ong S, Fowler DM, Maly DJ#, Parallel Chemoselective Profiling for Mapping Protein Structure, Cell Chem. Biol., 2020, 27, 8, 1084-1096.
4. Fang L, Chakraborty S, Dieter EM, Potter ZE, Lombard CK, Maly DJ#, Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes, J. Am. Chem. Soc., 2019, 141, 30, 11912-11922.
3. Chakraborty S, Inukai T, Fang L, Golkowski M, Maly DJ#, Targeting Dynamic ATP-Binding Site Features Allows Discrimination Between Highly Homologous Protein Kinases, ACS Chem. Biol., 2019, 14, 6, 1249-1259.
2. #Ahler E, #Register AC, Chakraborty S, Fang L, Dieter EM, Sitko KA, Vidadala R, Trevillian BM, Golkowski M, Gelman H, Stephany JJ, Rubin AF, Merritt EA, Fowler DM, Maly DJ#, A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions, Mol. Cell, 2019, 74, 393-408.
1. Li S, Fang L, Zhong J, Shen J, Xu H, Yang Y, Hou S, Bian Q#, Catalytic Asymmetric Synthesis of the Colorado Potato Beetle Pheromone and Its Enantiomer, Tetrahedron: Asymmetry, 2014, 25, 591-595.