Independent Research

Members of the Fang lab in Bold

# indicates equal contribution; * indicates corresponding authors

2026

20. Shentu J, Jiang Z, Tan Q, Fang L*, Structure-Encoded Oxidation Enables Nucleotide-resolved RNA Editing, Conjugation, and Structural Probing, Angew. Chem. Int. Ed., 2026, e1434064. [Link][PDF][Patent]

2025

19. Choi J, Jung TU, Cabanting F, Song J, Park C, Hwang S, Kang JY, Fang L, Jun YW*, Harnessing Deaminated DNA to Modulate mRNA Translation for Controlled and Sequential Protein Expression, Angew. Chem. Int. Ed., 2025, 64(52), e16389. [PDF]

Before Westlake

18. Stoddard EG, Perera GK, Fang L, Zhong Y, Potter ZE, Brush DS, Simon JJ, Golkowski M, Maly DJ*, Mek Interactions Tune Raf Kinase Sensitivity to Conformation-selective Inhibition, Nat. Chem. Biol., 2026, In press. [BioRxiv]

17. Fang L#, Zhong W#, Xiao L, Bravo S, Shioi R, Lee A, Bravo CH, Kool ET*, Localized 2´-OH Acylation at Poly(A) Extends mRNA Translation, J. Am. Chem. Soc., 2025, 147(37), 34027-34033. [Patent available]

16. Pandit B, Fang L, Kool ET, Royzen M*, Reversible RNA Acylation Using Bio-Orthogonal Chemistry Enables Temporal Control of CRISPR-Cas9 Nuclease Activity, ACS Chem. Biol.,  2024, 19(8), 1719-1724. 

15. Xiao L, Fang L, Zhong W, Kool ET*, RNA infrastructure profiling illuminates transcriptome structure in crowded spaces, Cell Chem. Biol., 2024, 31(12), 2156-2167.e2155.

14. Fang L, Velema WA, Lee Y, Xiao L, Mohsen MG, Kietrys AM, Kool ET*, Pervasive Transcriptome Interactions of Protein-Targeted Drugs, Nat. Chem., 2023, 15, 1374-1383. 

13. Fang L, Xiao L, Jun YW, Onishi Y, Kool ET*, Reversible 2´-OH Acylation Enhances RNA stability, Nat. Chem., 2023, 15, 1296-1305. [Patent available]

12. Fang L, Kool ET*, Reactivity-Based RNA Profiling for Analyzing Transcriptome Interactions of Small Molecules in Human Cells, STAR Protocols, 2023, 4, 102670. 

11. Xiao L, Fang L, Kool ET*, 2´-OH as a Universal Handle for Studying Intracellular RNAs, Cell Chem. Biol., 2023, 31, 110-124. Review article. 

10. Xiao L, Fang L, Chatterjee S, Kool ET*, Diverse Reagent Scaffolds Provide Differential Selectivity of 2´-OH Acylation in RNA, J. Am. Chem. Soc., 2023, 145, 143-151. 

9. #Chakraborty S, #Ahler E, Simon JJ, Fang L, Potter ZE, Sitko KA, Stephany JJ, Guttman M, Fowler DM, Maly DJ*, Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to the dynamics of the catalytic domain, Cell Chem. Biol., 2023, 23, 2451-9456. 

8. Xiao L, Fang L, Kool ET*, Acylation Probing of ‘Generic’ RNA Libraries Reveals Critical Influence of Loop Constraints on Reactivity, Cell Chem. Biol., 2022, 29, 1–12. 

7. Fang L, Vilas-Boas J, Chakraborty S, Potter ZE, Register AC, Seeliger MA, Maly DJ*, How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture, ACS Chem. Biol., 2020, 15, 7, 2005-2016.

6. Fang L, Maly DJ*, Finding the Right Key to the Lock: A Chemical and Genetic Toolkit for Interrogating DCLK1, Cell Chem. Biol., 2020, 27, 10, 1221-1223. Preview article. 

5. Potter ZE, Lau H, Chakraborty S, Fang L, Guttman M, Ong S, Fowler DM, Maly DJ*, Parallel Chemoselective Profiling for Mapping Protein Structure, Cell Chem. Biol., 2020, 27, 8, 1084-1096. 

4. Fang L, Chakraborty S, Dieter EM, Potter ZE, Lombard CK, Maly DJ*, Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes, J. Am. Chem. Soc., 2019, 141, 30, 11912-11922. 

3. Chakraborty S, Inukai T, Fang L, Golkowski M, Maly DJ*, Targeting Dynamic ATP-Binding Site Features Allows Discrimination Between Highly Homologous Protein Kinases, ACS Chem. Biol., 2019, 14, 6, 1249-1259. 

2. #Ahler E, #Register AC, Chakraborty S, Fang L, Dieter EM, Sitko KA, Vidadala R, Trevillian BM, Golkowski M, Gelman H, Stephany JJ, Rubin AF, Merritt EA, Fowler DM, Maly DJ*, A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions, Mol. Cell, 2019, 74, 393-408. 

1. Li S, Fang L, Zhong J, Shen J, Xu H, Yang Y, Hou S, Bian Q*, Catalytic Asymmetric Synthesis of the Colorado Potato Beetle Pheromone and Its Enantiomer, Tetrahedron: Asymmetry, 2014, 25, 591-595.