Discovering RNA Functions  with Activity-Based Sequencing Tools	Mapping RNA Ligandability on  A Global Scale	Reprogramming RNA functions with Small Molecules
We aim to develop activity-based tools to discover functional RNAs transcriptome-wide.	We apply the state-of-the-art chemical and transcriptomic analytic tools to map RNA ligandability.	We aim to innovate small molecules to harness cellular machineries for controlling RNA functions.

The Fang laboratory aims to dissect small-molecule regulation of RNA functions in human physiology & diseases by developing and applying cutting-edge chemical and genomic analysis tools. In parallel, we aim to engineer next-generation small-molecule modulators that harness the native cellular machineries to control RNA functions.

It’s an exciting era for exploring the human transcriptome with small molecules. Despite substantial progress, various fundamental questions remain: Which structured RNA loci are ligandable? What is the chemical space of RNA-interacting ligands? How do small molecules modulate RNA structure, interactions, and functions?

 Technical challenges largely limit our ability to answer these questions, and our lab aims to develop new methodologies to bridge these gaps.